src inhibitor1 Search Results


src 1 inhibitor  (MedChemExpress)
94
MedChemExpress src 1 inhibitor
Src 1 Inhibitor, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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src inhibitor 1  (TargetMol)
93
TargetMol src inhibitor 1
Src Inhibitor 1, supplied by TargetMol, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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s 7979 src inhibitor 1 selleck chemical  (Selleck Chemicals)
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Selleck Chemicals s 7979 src inhibitor 1 selleck chemical
S 7979 Src Inhibitor 1 Selleck Chemical, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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rabbit anti npepps  (Boster Bio)
93
Boster Bio rabbit anti npepps
Rabbit Anti Npepps, supplied by Boster Bio, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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src inhibitor  (Merck KGaA)
90
Merck KGaA src inhibitor
Src Inhibitor, supplied by Merck KGaA, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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src inhibitor-1  (Merck & Co)
90
Merck & Co src inhibitor-1
Merged images of peripheral blood human neutrophils stained with Hoechst (blue) and Sytox Green (green) after stimulation for 4hrs with TNF-α (5 ng/ml) and anti-MPO antibody (5 μg/mL) on fibronectin-coated plates with or without 30 minutes pre-incubation with inhibitors (A). Representative FlowJo plots of CellProfiler cell measurements (B), and percentage NETs (C) for each condition. Data points represent technical replicates from one of three independent experiments with different donors. MPO – anti-MPO antibody, SYG – Sytox Green, HO – Hoechst 33342, FAKi – Focal adhesion kinase inhibitor (20 μM), SRCi – Src kinase <t>inhibitor-1</t> (1 μM), PP1 – Src kinase inhibitor (2.5 μM), CytB – actin filament inhibitor cytochalasin B (10 μM), PI3Ki – PI3K inhibitor copanlisib (200 nM). # # # p < 0.001 between mock and anti-MPO stimulated, *** p < 0.001 between no inhibition and with respective inhibitor.
Src Inhibitor 1, supplied by Merck & Co, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/src inhibitor-1/product/Merck & Co
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src inhibitor 1 (ski)  (Novartis)
90
Novartis src inhibitor 1 (ski)
Merged images of peripheral blood human neutrophils stained with Hoechst (blue) and Sytox Green (green) after stimulation for 4hrs with TNF-α (5 ng/ml) and anti-MPO antibody (5 μg/mL) on fibronectin-coated plates with or without 30 minutes pre-incubation with inhibitors (A). Representative FlowJo plots of CellProfiler cell measurements (B), and percentage NETs (C) for each condition. Data points represent technical replicates from one of three independent experiments with different donors. MPO – anti-MPO antibody, SYG – Sytox Green, HO – Hoechst 33342, FAKi – Focal adhesion kinase inhibitor (20 μM), SRCi – Src kinase <t>inhibitor-1</t> (1 μM), PP1 – Src kinase inhibitor (2.5 μM), CytB – actin filament inhibitor cytochalasin B (10 μM), PI3Ki – PI3K inhibitor copanlisib (200 nM). # # # p < 0.001 between mock and anti-MPO stimulated, *** p < 0.001 between no inhibition and with respective inhibitor.
Src Inhibitor 1 (Ski), supplied by Novartis, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/src inhibitor 1 (ski)/product/Novartis
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Image Search Results


Merged images of peripheral blood human neutrophils stained with Hoechst (blue) and Sytox Green (green) after stimulation for 4hrs with TNF-α (5 ng/ml) and anti-MPO antibody (5 μg/mL) on fibronectin-coated plates with or without 30 minutes pre-incubation with inhibitors (A). Representative FlowJo plots of CellProfiler cell measurements (B), and percentage NETs (C) for each condition. Data points represent technical replicates from one of three independent experiments with different donors. MPO – anti-MPO antibody, SYG – Sytox Green, HO – Hoechst 33342, FAKi – Focal adhesion kinase inhibitor (20 μM), SRCi – Src kinase inhibitor-1 (1 μM), PP1 – Src kinase inhibitor (2.5 μM), CytB – actin filament inhibitor cytochalasin B (10 μM), PI3Ki – PI3K inhibitor copanlisib (200 nM). # # # p < 0.001 between mock and anti-MPO stimulated, *** p < 0.001 between no inhibition and with respective inhibitor.

Journal: bioRxiv

Article Title: Cellular adhesion is a controlling factor in neutrophil extracellular trap formation induced by antineutrophil cytoplasmic antibodies

doi: 10.1101/2021.10.19.465054

Figure Lengend Snippet: Merged images of peripheral blood human neutrophils stained with Hoechst (blue) and Sytox Green (green) after stimulation for 4hrs with TNF-α (5 ng/ml) and anti-MPO antibody (5 μg/mL) on fibronectin-coated plates with or without 30 minutes pre-incubation with inhibitors (A). Representative FlowJo plots of CellProfiler cell measurements (B), and percentage NETs (C) for each condition. Data points represent technical replicates from one of three independent experiments with different donors. MPO – anti-MPO antibody, SYG – Sytox Green, HO – Hoechst 33342, FAKi – Focal adhesion kinase inhibitor (20 μM), SRCi – Src kinase inhibitor-1 (1 μM), PP1 – Src kinase inhibitor (2.5 μM), CytB – actin filament inhibitor cytochalasin B (10 μM), PI3Ki – PI3K inhibitor copanlisib (200 nM). # # # p < 0.001 between mock and anti-MPO stimulated, *** p < 0.001 between no inhibition and with respective inhibitor.

Article Snippet: In some cases, neutrophils were pre-incubated with 20 μM focal adhesion kinase (FAK) inhibitor-1 (Merck, Darmstadt, Germany), 1 μM Src inhibitor-1 (Merck), 2.5 μM Src inhibitor PP1 (Cayman Chemical, Ann Arbor, MI), 10 μM actin inhibitor cytochalasin B from Helminthosporium dematioideum (Nacalai Tesque, Kyoto, Japan), 200nM phosphoinositide 3-kinase (PI3K) inhibitor copanlisib (Cayman Chemical), 25 μM of the MEK inhibitor U0126 (Nacalai Tesque), 100 μM of the ROS scavenger pyrocatechol (Sigma-Aldrich), 10 μM of the NADPH oxidase inhibitor DPI (Sigma-Aldrich), 20 μM of the NE inhibitor GW 311616A (Axon Medchem, Netherlands), or 10 μg/ml azide-free blocking antibodies for integrin β1 (CD29, clone: TS2/16), β2 (CD18, clone: TS1/18), β3 (CD61, clone: 23C6), α5 (CD49e, clone: NKI-SAM-1), αL (CD11a, clone: HI111), αM (CD11b, clone: M1/70), αX (CD11c, clone: 3.9) (all Biolegend, San Diego, CA), or α9 (CD49i, clone: Y9A2, Merck) for 30 minutes at 37 °C before stimulation, with gentle agitation every 10 minutes to prevent cell settling.

Techniques: Staining, Incubation, Inhibition

Representative FlowJo plots of CellProfiler cell measurements (A), and percentage NETs (B) of neutrophils stimulated for 4hrs with TNF-α (5 ng/ml) and anti-MPO antibody (5 μg/mL) on fibronectin-coated plates with or without 30 minutes pre-incubation with inhibitors. Data points represent technical replicates from one of three independent experiments with different donors. Measurement of ROS release using a fluorometric kit monitored every two minutes over three hours. Mean and SEM is shown for four technical replicates. Data for each inhibitor is shown on a separate plot for clarity, with the TNF-α and anti-MPO stimulated results replicated from the same data. Significance is indicated for the final time point. MPO – anti-MPO antibody, FAKi – Focal adhesion kinase inhibitor (20 μM), SRCi – Src kinase inhibitor-1 (1 μM), PP1 – Src kinase inhibitor (2.5 μM), CytB – actin filament inhibitor cytochalasin B (10 μM), PI3Ki – PI3K inhibitor copanlisib (200 nM), MEKi – MEK inhibitor U0126 (25 μM), NOXi – NADPH oxidase inhibitor DPI (10 μM), Pyrocatechol – ROS scavenger (100 μM), NEi – neutrophil elastase inhibitor GW 311616A (20 μM). # # # p < 0.001, # # p < 0.01 between TNF-α and TNF-α + anti-MPO stimulated, *** p < 0.001, ** p < 0.01 between no inhibition and with respective inhibitor.

Journal: bioRxiv

Article Title: Cellular adhesion is a controlling factor in neutrophil extracellular trap formation induced by antineutrophil cytoplasmic antibodies

doi: 10.1101/2021.10.19.465054

Figure Lengend Snippet: Representative FlowJo plots of CellProfiler cell measurements (A), and percentage NETs (B) of neutrophils stimulated for 4hrs with TNF-α (5 ng/ml) and anti-MPO antibody (5 μg/mL) on fibronectin-coated plates with or without 30 minutes pre-incubation with inhibitors. Data points represent technical replicates from one of three independent experiments with different donors. Measurement of ROS release using a fluorometric kit monitored every two minutes over three hours. Mean and SEM is shown for four technical replicates. Data for each inhibitor is shown on a separate plot for clarity, with the TNF-α and anti-MPO stimulated results replicated from the same data. Significance is indicated for the final time point. MPO – anti-MPO antibody, FAKi – Focal adhesion kinase inhibitor (20 μM), SRCi – Src kinase inhibitor-1 (1 μM), PP1 – Src kinase inhibitor (2.5 μM), CytB – actin filament inhibitor cytochalasin B (10 μM), PI3Ki – PI3K inhibitor copanlisib (200 nM), MEKi – MEK inhibitor U0126 (25 μM), NOXi – NADPH oxidase inhibitor DPI (10 μM), Pyrocatechol – ROS scavenger (100 μM), NEi – neutrophil elastase inhibitor GW 311616A (20 μM). # # # p < 0.001, # # p < 0.01 between TNF-α and TNF-α + anti-MPO stimulated, *** p < 0.001, ** p < 0.01 between no inhibition and with respective inhibitor.

Article Snippet: In some cases, neutrophils were pre-incubated with 20 μM focal adhesion kinase (FAK) inhibitor-1 (Merck, Darmstadt, Germany), 1 μM Src inhibitor-1 (Merck), 2.5 μM Src inhibitor PP1 (Cayman Chemical, Ann Arbor, MI), 10 μM actin inhibitor cytochalasin B from Helminthosporium dematioideum (Nacalai Tesque, Kyoto, Japan), 200nM phosphoinositide 3-kinase (PI3K) inhibitor copanlisib (Cayman Chemical), 25 μM of the MEK inhibitor U0126 (Nacalai Tesque), 100 μM of the ROS scavenger pyrocatechol (Sigma-Aldrich), 10 μM of the NADPH oxidase inhibitor DPI (Sigma-Aldrich), 20 μM of the NE inhibitor GW 311616A (Axon Medchem, Netherlands), or 10 μg/ml azide-free blocking antibodies for integrin β1 (CD29, clone: TS2/16), β2 (CD18, clone: TS1/18), β3 (CD61, clone: 23C6), α5 (CD49e, clone: NKI-SAM-1), αL (CD11a, clone: HI111), αM (CD11b, clone: M1/70), αX (CD11c, clone: 3.9) (all Biolegend, San Diego, CA), or α9 (CD49i, clone: Y9A2, Merck) for 30 minutes at 37 °C before stimulation, with gentle agitation every 10 minutes to prevent cell settling.

Techniques: Incubation, Inhibition

Merged images of peripheral blood human neutrophils stained with Hoechst (blue) and Sytox Green (green) after stimulation for 4hrs with TNF-α (5 ng/ml) and isolated serum IgG (40 μg/mL) from ANCA vasculitis patients (N = 10) or healthy controls (N = 4), with or without 30 minutes pre-incubation with inhibitors (A). Representative plots of CellProfiler cell measurements (B), and percentage NETs (C) for each condition. For serum IgG, data points represent each patient or healthy control. For mock, data points represent technical replicates. Results are from one of three independent experiments with different healthy neutrophil donors. SYG – Sytox Green, HO – Hoechst 33342, FAKi – Focal adhesion kinase inhibitor (20 μM), SRCi – Src kinase inhibitor-1 (1 μM), PP1 – Src kinase inhibitor (2.5 μM), CytB – actin filament inhibitor cytochalasin B (10 μM), PI3Ki – PI3K inhibitor copanlisib (200 nM). # # p < 0.01 between healthy and ANCA serum IgG, *** p < 0.001 between no inhibition and with respective inhibitor.

Journal: bioRxiv

Article Title: Cellular adhesion is a controlling factor in neutrophil extracellular trap formation induced by antineutrophil cytoplasmic antibodies

doi: 10.1101/2021.10.19.465054

Figure Lengend Snippet: Merged images of peripheral blood human neutrophils stained with Hoechst (blue) and Sytox Green (green) after stimulation for 4hrs with TNF-α (5 ng/ml) and isolated serum IgG (40 μg/mL) from ANCA vasculitis patients (N = 10) or healthy controls (N = 4), with or without 30 minutes pre-incubation with inhibitors (A). Representative plots of CellProfiler cell measurements (B), and percentage NETs (C) for each condition. For serum IgG, data points represent each patient or healthy control. For mock, data points represent technical replicates. Results are from one of three independent experiments with different healthy neutrophil donors. SYG – Sytox Green, HO – Hoechst 33342, FAKi – Focal adhesion kinase inhibitor (20 μM), SRCi – Src kinase inhibitor-1 (1 μM), PP1 – Src kinase inhibitor (2.5 μM), CytB – actin filament inhibitor cytochalasin B (10 μM), PI3Ki – PI3K inhibitor copanlisib (200 nM). # # p < 0.01 between healthy and ANCA serum IgG, *** p < 0.001 between no inhibition and with respective inhibitor.

Article Snippet: In some cases, neutrophils were pre-incubated with 20 μM focal adhesion kinase (FAK) inhibitor-1 (Merck, Darmstadt, Germany), 1 μM Src inhibitor-1 (Merck), 2.5 μM Src inhibitor PP1 (Cayman Chemical, Ann Arbor, MI), 10 μM actin inhibitor cytochalasin B from Helminthosporium dematioideum (Nacalai Tesque, Kyoto, Japan), 200nM phosphoinositide 3-kinase (PI3K) inhibitor copanlisib (Cayman Chemical), 25 μM of the MEK inhibitor U0126 (Nacalai Tesque), 100 μM of the ROS scavenger pyrocatechol (Sigma-Aldrich), 10 μM of the NADPH oxidase inhibitor DPI (Sigma-Aldrich), 20 μM of the NE inhibitor GW 311616A (Axon Medchem, Netherlands), or 10 μg/ml azide-free blocking antibodies for integrin β1 (CD29, clone: TS2/16), β2 (CD18, clone: TS1/18), β3 (CD61, clone: 23C6), α5 (CD49e, clone: NKI-SAM-1), αL (CD11a, clone: HI111), αM (CD11b, clone: M1/70), αX (CD11c, clone: 3.9) (all Biolegend, San Diego, CA), or α9 (CD49i, clone: Y9A2, Merck) for 30 minutes at 37 °C before stimulation, with gentle agitation every 10 minutes to prevent cell settling.

Techniques: Staining, Isolation, Incubation, Inhibition